The relationship between pulse pressure, insulin resistance, and beta cell function in non-diabetic Korean adults.

Abstract

The present study was conducted to assess the association of pulse pressure (PP) with insulin resistance and beta cell function in Korean non-diabetic populations. This study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older. A multivariate analysis revealed that systolic blood pressure (SBP) (β=0.089, 95% confidence interval [CI], 0.004-0.011; p<0.001), diastolic blood pressure (DBP) (β=-0.057, 95% CI -0.014 to -0.003; p=0.002), and PP (β=0.069, 95% CI 0.004-0.011; p<0.001) were significant factors determining the homeostasis model assessment of insulin resistance (HOMA-IR). SBP (β=0.070, 95% CI, 0.113-0.420; p=0.001), DBP (β=-0.068, 95% CI -0.676 to -0.203; p<0.001), and PP (β=0.050, 95% CI 0.115-0.422; p=0.001) were significant factors determining the homeostasis model assessment of beta cell function (HOMA-B). In the analysis of covariance test, after adjusting for related variables (except age), the quartiles of PP were not associated with HOMA-IR (p=0.191) and were inversely associated with HOMA-B (p<0.001). However, when further adjusting for age, the quartiles of PP were positively associated with both HOMA-IR (p<0.001) and HOMA-B (p=0.027). PP was positively associated with insulin resistance and beta cell function in non-diabetic Korean adults.