Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30862789.
- Also identified by DOI 10.1038/s41467-019-08859-x and PMC identifier 6414514.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It is modulated through a dynamic interplay between ADP-ribose readers, writers and erasers. While ADP-ribose synthesis has been studied and reviewed extensively, ADP-ribose processing by erasing enzymes has received comparably less attention. However, major progress in the mass spectrometric identification of ADP-ribosylated residues and the biochemical characterization of ADP-ribose erasers has substantially expanded our knowledge of ADP-ribosylation dynamics. Herein, we describe recent insights into the biology of ADP-ribose erasers and discuss the intricately orchestrated cellular processes to switch off ADP-ribose-dependent mechanisms.
Medical subject headings
- ADP Ribose Transferases
- ADP-Ribosylation
- Adenosine Diphosphate Ribose
- Glycoside Hydrolases
- Poly(ADP-ribose) Polymerases