Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30867415.
- Also identified by DOI 10.1038/s41467-019-09069-1 and PMC identifier 6416470.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of Drosophila. Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABA<sub>B</sub>- and GABA<sub>A</sub> receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specific crosstalk between the attractant- and repellent-responsive circuits. This inhibitory interaction biases the behavioral output. Such a form of selective lateral inhibition represents a crucial neuronal mechanism in the processing of conflicting sensory information.
Medical subject headings
- Drosophila melanogaster
- Odorants
- Olfactory Bulb
- Olfactory Pathways
- Olfactory Perception