Innate immunity, inflammation and tumour progression: double-edged swords.
Where this comes from
- Record sourced from PubMed, PMID 30873708.
- Also identified by DOI 10.1111/joim.12886 and PMC identifier 7174018.
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Abstract
Components of the cellular and the humoral arm of the immune system are essential elements of the tumour microenvironment (TME). The TME includes tumour-associated macrophages which have served as a paradigm for the cancer-promoting inflammation. Cytokines, IL-1 in particular, and complement have emerged as important players in tumour promotion. On the other hand, myeloid cells, innate lymphoid cells and complement have the potential, if unleashed, to mediate anticancer resistance. Targeting checkpoints restraining innate immunity, macrophages and natural killer (NK) cells in particular holds promise as a therapeutic strategy.
Medical subject headings
- Immunity, Innate
- Inflammation
- Neoplasms