Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30874623.
- Also identified by DOI 10.1038/s41583-019-0148-y.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The cerebral cortex is an evolutionarily advanced brain structure that computes higher motor, sensory and cognitive functions. Its complex organization reflects the exquisite cell migration and differentiation patterns that take place during embryogenesis. Recent evidence supports an essential role for cell migration in shaping the developing cerebral cortex via direct cellular contacts and spatially organized diffusible cues that regulate the establishment of its cytoarchitecture and function. Identifying the nature of the crosstalk between cell populations at play during brain development is key to understanding how cerebral cortical morphogenesis proceeds in health and disease.
Medical subject headings
- Cell Communication
- Cell Movement
- Cerebral Cortex
- Morphogenesis
- Neurogenesis