Monoclonal Gammopathy, Arthralgias, and Recurrent Fever Syndrome: A New Autoinflammatory Syndrome?

Terré, Alexandre; Talbot, Alexis; Louvrier, Camille; Picque, Jean Baptiste; Mahévas, Matthieu; Boutboul, David; Amselem, Serge; Giurgea, Irina et al. · J Rheumatol · 2019

retrospective_cohort · Level III

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Abstract

To describe a new autoinflammatory syndrome with recurrent fever and monoclonal gammopathy that differs from Schnitzler syndrome. We conducted a retrospective study of patients with monoclonal gammopathy and recurrent fever of unknown origin. Five patients were studied; median age at onset of symptoms was 44 years. Median frequency of fever attacks was 6 episodes per year. In the absence of treatment, the median duration of fevers was 3 days. This new autoinflammatory syndrome is defined by an association among monoclonal gammopathy, arthralgias, and recurrent fever.

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