Assessing Associations of Synovial Perfusion, Cartilage Quality, and Outcome in Rheumatoid Arthritis Using Dynamic Contrast-enhanced Magnetic Resonance Imaging.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 30877219.
- Also identified by DOI 10.3899/jrheum.180832.
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Abstract
To assess associations of synovial perfusion, cartilage quality, and outcome in rheumatoid arthritis (RA). Synovial perfusion and cartilage quality were assessed by dynamic contrast-enhanced magnetic resonance imaging in metacarpophalangeal joints of 28 treatment-naive patients with RA at baseline and at 3 and 6 months after methotrexate. Analysis was by linear mixed modeling. Synovial perfusion variables were associated with remission (p < 0.05) and cartilage quality (p < 0.004). Maximum synovial enhancement was associated to European League Against Rheumatism response (p < 0.05). Synovial perfusion improved in nonresponders over time (p < 0.05). Synovial perfusion relates to remission, response, and cartilage quality in a cohort of therapy-naive patients with early RA.
Medical subject headings
- Arthritis, Rheumatoid
- Cartilage
- Contrast Media
- Magnetic Resonance Imaging
- Metacarpophalangeal Joint
- Patient Outcome Assessment
- Synovial Membrane
- Synovitis