Correlates of T₅₀ and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study.

Abstract

T₅₀ is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T₅₀ indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T₅₀ nor the relationships of T₅₀ with bone mineral density (BMD) are known. We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T₅₀ and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T₅₀ and hip and spine BMD in multivariable models. Older age was associated with shorter T₅₀. Kidney function tended to be lower in those with shorter T₅₀ and the prevalence of CVD and peripheral arterial disease in those with shorter T₅₀, albeit these findings did not achieve statistical significance. We found no statistically significant associations between T₅₀ and total hip or total spine BMD in either unadjusted or multivariable adjusted models. T₅₀, a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T₅₀ may give insights to CVD in the general population above and beyond traditional risk factors.