Radial MP2RAGE sequence for rapid 3D T₁ mapping of mouse abdomen: application to hepatic metastases.

Abstract

The T₁ longitudinal recovery time is regarded as a biomarker of cancer treatment efficiency. In this scope, the Magnetization Prepared 2 RApid Gradient Echo (MP2RAGE) sequence relevantly complies with fast 3D T₁ mapping. Nevertheless, with its Cartesian encoding scheme, it is very sensitive to respiratory motion. Consequently, a radial encoding scheme was implemented for the detection and T₁ measurement of hepatic metastases in mice at 7T. A 3D radial encoding scheme was developed using a golden angle distribution for the k-space trajectories. As in that case, each projection contributes to the image contrast, the signal equations had to be modified. Phantoms containing increasing gadoteridol concentrations were used to determine the accuracy of the sequence in vitro. Healthy mice were repetitively scanned to assess the reproducibility of the T₁ values. The growth of hepatic metastases was monitored. Undersampling robustness was also evaluated. The accuracy of the T₁ values obtained with the radial MP2RAGE sequence was > 90% compared to the Inversion-Recovery sequence. The motion robustness of this new sequence also enabled repeatable T₁ measurements on abdominal organs. Hepatic metastases of less than 1-mm diameter were easily detected and T₁ heterogeneities within the metastasis and between the metastases within the same animal were measured. With a twofold acceleration factor using undersampling, high-quality 3D T₁ abdominal maps were achieved in 9 min. The radial MP2RAGE sequence could be used for fast 3D T₁ mapping, to detect and characterize metastases in regions subjected to respiratory motion. • The Cartesian encoding of the MP2RAGE sequence was modified to a radial encoding. The modified sequence enabled accurate T ₁ measurements on phantoms and on abdominal organs of mice. • Hepatic metastases were easily detected due to high contrast. Heterogeneity in T ₁ was measured within the metastases and between each metastasis within the same animal. • As implementation of this sequence does not require specific hardware, we expect that it could be readily available for clinical practice in humans.