<i>PTEN</i> Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 30888866.
- Also identified by DOI 10.2214/AJR.18.20743.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
<b>OBJECTIVE.</b> The objective of our study was to investigate whether phosphatase and tensin homolog (<i>PTEN</i>) expression is associated with clinicopathologic features and multiparametric MRI findings in prostate cancer. <b>MATERIALS AND METHODS.</b> Forty-three patients with prostate cancer who underwent radical prostatectomy were included. Index tumor was identified on pretreatment MRI and delineated in the area that correlated best with histopathology results. The apparent diffusion coefficient (ADC) from DWI and pharmacokinetic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) using the extended Tofts model (K<sup>trans</sup>, k<sub>ep</sub>, <i>v<sub>e</sub></i>, and <i>v<sub>p</sub></i>) within the tumor were estimated. The following clinicopathologic parameters were assessed: pretreatment serum levels of prostate-specific antigen, disseminated tumor cell status, age, Gleason score, tumor size, extraprostatic extension (EPE), tumor location, and lymph node metastases. Gene expression profiles were acquired in biopsies from the tumor using bead arrays, and validated using reverse transcription quantitative polymerase chain reaction (RT-qPCR) on a different part of the biopsy. <b>RESULTS.</b> Based on bead arrays (<i>p</i> = 0.006) and RT-qPCR (<i>p</i> = 0.03) data, a significantly lower ADC was found in tumors with low <i>PTEN</i> expression. Moreover, <i>PTEN</i> expression was negatively associated with lymph node metastases (bead arrays, <i>p</i> = 0.008; RT-qPCR, <i>p</i> < 0.001). A weak but significant association between <i>PTEN</i> expression, EPE (<i>p</i> = 0.048), and Gleason score (<i>p</i> = 0.028) was revealed on bead arrays. ADC was negatively correlated with Gleason score (<i>p</i> = 0.001) and tumor size (<i>p</i> = 0.023). No association among DCE parameters, <i>PTEN</i> expression, and clinicopathologic features was found. <b>CONCLUSION.</b> ADC derived from DWI may be useful in selecting patients with potentially aggressive tumor caused by <i>PTEN</i> deficiency.