Genetics of Common, Complex Coronary Artery Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30901535.
- Also identified by DOI 10.1016/j.cell.2019.02.015.
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Abstract
Coronary artery disease represents the leading cause of death worldwide, sparing no nation, ethnicity, or economic stratum. Coronary artery disease is partly heritable. While enormous effort has been devoted to understanding the genetic basis of coronary artery disease and other common, complex cardiovascular diseases, key challenges have emerged in gene discovery, in understanding how DNA variants connect to function, and in translation of genetics to the clinic. We discuss these challenges as well as promising opportunities to bring the work closer to fruition.
Medical subject headings
- Coronary Artery Disease