Gene-Environment Interaction in the Era of Precision Medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30901546.
- Also identified by DOI 10.1016/j.cell.2019.03.004 and PMC identifier 8108774.
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Abstract
Innovative analytical frameworks are required to capture the complex gene-environment interactions. We investigate the insufficiency of commonly used models for disease genome analysis and suggest considering genetic interactions in complex diseases. For non-genetic factors, we study the emerging wearable technologies that have enabled quantification of physiological and environmental factors at an unprecedented breadth and depth. We propose a Bayesian framework to hierarchically model personalized gene-environmental interaction to enable precision health and medicine.
Medical subject headings
- Precision Medicine
- Wearable Electronic Devices