A knowledge-guided kidney cell census-reconciling bulk omics with cellular heterogeneity?
Level V
Where this comes from
- Record sourced from PubMed, PMID 30904059.
- Also identified by DOI 10.1016/j.kint.2018.12.016.
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Abstract
Clark et al. present a curated knowledge-based census of 43 known canonical kidney cell types, based on calculated contribution to total kidney mass and expression of molecular markers. Their study illustrates limitations of bulk transcriptomics but also provides guidance to their fruitful interpretation. In the light of their findings, the use of bulk sequencing datasets in conjunction with single-cell transcriptomics could contribute to the exploitation of integrative omics analyses in kidney research.
Medical subject headings
- Censuses
- RNA