Don't trick me twice!
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30904060.
- Also identified by DOI 10.1016/j.kint.2018.12.004.
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Abstract
Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of transition from acute kidney injury to chronic kidney disease.
Medical subject headings
- Acute Kidney Injury
- Renal Insufficiency, Chronic