Distinct phenotype of CD4<sup>+</sup> T cells driving celiac disease identified in multiple autoimmune conditions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30911136.
- Also identified by DOI 10.1038/s41591-019-0403-9 and PMC identifier 6647859.
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Abstract
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4<sup>+</sup> T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4<sup>+</sup> T cells specific for disease-driving antigens in multiple autoimmune conditions.
Medical subject headings
- Autoimmune Diseases
- CD4-Positive T-Lymphocytes
- Celiac Disease