Heroin addiction engages negative emotional learning brain circuits in rats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30913040.
- Also identified by DOI 10.1172/JCI125534 and PMC identifier 6546476.
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Abstract
Opioid use disorder (OUD) is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological insights into the drivers of the current opioid crisis.
Medical subject headings
- Amygdala
- Emotions
- Heroin Dependence
- Hypothalamus
- Learning
- Magnetic Resonance Imaging
- Nerve Net