Role of hydrogen sulfide in the musculoskeletal system.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30928641.
- Also identified by DOI 10.1016/j.bone.2019.03.034 and PMC identifier 6570498.
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Abstract
Hydrogen sulfide (H<sub>2</sub>S) has been known as a gasotransmitter, and it contributes to various physiological and pathological processes. Multiple enzymes such as cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous H<sub>2</sub>S, and these are differentially expressed in the various tissue systems including the skeletal system. However, abnormal H<sub>2</sub>S production is associated with deregulation of the signaling cascade and imbalanced tissue homeostasis. Several studies have previously provided evidence showing the essential regulatory action of H<sub>2</sub>S in skeletal homeostasis. In this review, we have emphasized the novel function of H<sub>2</sub>S in both bone and skeletal muscle anabolism, in particular. Additionally, we also reviewed the molecular and epigenetic basis of H<sub>2</sub>S signaling in bone development and skeletal muscle function.
Medical subject headings
- Hydrogen Sulfide
- Musculoskeletal System