Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment.

Polsfuss, Silke; Hofmann-Thiel, Sabine; Merker, Matthias; Krieger, David; Niemann, Stefan; Rüssmann, Holger; Schönfeld, Nicolas; Hoffmann, Harald et al. · Clin Infect Dis · 2019

case_report · Level V

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Abstract

Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

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