Applying a commercial atlas-based synthetic Computed Tomography algorithm to patients with hip prostheses for prostate Magnetic Resonance-only radiotherapy.

Abstract

Magnetic Resonance (MR)-only prostate radiotherapy has recently been clinically implemented using commercial synthetic Computed Tomography (sCT) algorithms. However patients with hip prostheses have been excluded from all MR-only research to date and assumed to require dedicated sCT algorithms. This study aimed to investigate the dosimetric accuracy of applying a commercial sCT algorithm, based on an atlas of patients without hip prostheses, to patients with prostheses. 18 patients with unilateral hip prostheses received MR and CT scans in the radiotherapy position. sCTs were generated from the MR using a commercial algorithm. The clinical Volumetric Modulated Arc Therapy (VMAT) plan, consisting of partial arcs which avoided the prosthesis, was recalculated using the sCT and the dose distribution compared. The mean isocentre dose difference was ΔD = (-0.4 ± 0.2)% (mean ± standard error of the mean (sem), range - 1.9%, 1.1%) and the mean differences in Planning Target Volume, bladder and rectum mean doses were ≤0.3%. The 3D global gamma pass rate with dose difference 1% and distance to agreement 1 mm within the body was Γ_Body^1/1 = (95.0 ± 0.5)% (sem) and within the 50% isodose volume, which excluded the prosthesis, was Γ_50%^1/1 = (98.5 ± 0.4)% (sem). The pass rate within the PTV was Γ_PTV^2/2 ≥ 99.7% for all patients, although for PTVs close (≤3.5 cm) to the prosthesis Γ_PTV^1/1 < 85% for three patients. The sCT did not accurately represent the prosthesis with a mean difference in radiological isocentre depth near the prosthesis of Δd_Outside^Rad = (15.8 ± 2.6) mm (sem). However inside the treatment plan arc the difference was Δd_Inside^Rad = (-1.8 ± 0.5) mm (sem). Using a commercial prostate sCT algorithm for patients with unilateral hip prostheses is dosimetrically accurate (<0.5%) as long as the routine prosthesis-avoidance treatment planning approach is used and the PTV is >3.5 cm from the prosthesis. This suggests MR-only prostate radiotherapy can be extended to patients with hip prostheses without requiring a specific sCT algorithm.