Metabolic Adaptation Fuels Lymph Node Metastasis.
Where this comes from
- Record sourced from PubMed, PMID 30943388.
- Also identified by DOI 10.1016/j.cmet.2019.03.006.
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Abstract
Many cancers metastasize regionally through lymphatics before metastasizing systemically through blood vessels. However, metastasis through blood has been studied much more extensively than metastasis through lymph. Recently in Science, Lee et al. (2019) offered new insight into lymph node metastasis by showing that melanoma cells must undergo metabolic changes during this process and that it is driven by localized accumulation of bile acids.
Medical subject headings
- Lymphatic Vessels
- Skin Neoplasms