Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30943389.
- Also identified by DOI 10.1016/j.cmet.2019.03.002.
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Abstract
Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. Recently in Nature, He et al. (2019) reported that gut intraepithelial T cells regulate GLP-1 bioavailability by capturing it on GLP-1 receptors and impacting L-cell numbers. This study delineates a novel endocrine-immune axis through which intestinal immune cells regulate whole-body metabolism.
Medical subject headings
- Cardiovascular Diseases
- Intraepithelial Lymphocytes