Discovery of False Elite Controllers: HIV Antibody-Positive RNA-Negative Blood Donors Found To Be on Antiretroviral Therapy.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 30950501.
- Also identified by DOI 10.1093/infdis/jiz145 and PMC identifier 6639597.
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Abstract
An increase in potential HIV elite controllers (EC) and anecdotal reports of antiretroviral therapy (ART) use among South African blood donors led us to verify EC status. Stored plasma samples from potential EC were tested for ART drugs. Demographic and temporal associations were examined using multivariable logistic regression. Of 226 potential EC, 150 (66.4%) had detectable ART with increasing prevalence by year (OR = 7.57 for 2016 vs 2010, 95% confidence interval, 1.96-32.17). False presumptive EC status due to undisclosed ART represents a growing proportion of potential EC donors in South Africa coincident with the country's ART rollout.
Medical subject headings
- Anti-Retroviral Agents
- Antibodies, Viral
- HIV
- HIV Infections
- RNA, Viral