Toward a Universal Solution: Editing Compatibility into Pluripotent Stem Cells.
editorial · Level V
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- Record sourced from PubMed, PMID 30951658.
- Also identified by DOI 10.1016/j.stem.2019.03.003.
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Abstract
In this issue of Cell Stem Cell, Xu et al. (2019) demonstrate that editing iPSCs' major histocompatibility antigens may potentially provide a small set of universally compatible stem cell lines for therapies. However, these modifications may result in patient minor histocompatibility responses and deficiencies in their T cell response repertoire to infection and cancer.
Medical subject headings
- Induced Pluripotent Stem Cells
- Pluripotent Stem Cells