Does Autophagy Promote Longevity? It Depends.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30951663.
- Also identified by DOI 10.1016/j.cell.2019.03.021.
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Abstract
Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.
Medical subject headings
- Autophagy
- Caenorhabditis elegans Proteins