A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30952637.
- Also identified by DOI 10.1158/1078-0432.CCR-19-0853.
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Abstract
Cancer-associated fibroblasts (CAF) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition and endows metastatic traits, which offers novel therapeutic potential in the clinical setting.<i>See related article by Sjöberg et al., p. 3702</i>.
Medical subject headings
- Cancer-Associated Fibroblasts