About Face: Molecular Aberrations in Head and Neck Mucosal Melanomas.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30952641.
- Also identified by DOI 10.1158/1078-0432.CCR-19-0658 and PMC identifier 7463422.
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Abstract
Detailed molecular characterization of a large cohort of mucosal melanomas, most arising from head and neck primaries, suggests that chromosomal translocations and other complex rearrangements have prognostic importance. CDK4 amplification is a frequent event in these rare tumors, and CDK4/6 inhibition may represent a rational clinical trial strategy.<i>See related article by Zhou et al., p. 3548</i>.
Medical subject headings
- Head and Neck Neoplasms
- Melanoma