Diabetic Cardiomyopathy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30973809.
- Also identified by DOI 10.1161/CIRCRESAHA.118.314665 and PMC identifier 6578576.
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Abstract
Diabetic cardiomyopathy was initially described as a human pathophysiological condition in which heart failure occurred in the absence of coronary artery disease, hypertension, and valvular heart disease. Recent studies in diabetic animal models identify decreased cardiomyocyte function as an important mediating mechanism for heart failure. Decreased cardiomyocyte function is in part mediated by abnormal mitochondrial calcium handling and a decreased level of free matrix calcium levels which could be a good target for new therapeutic interventions.
Medical subject headings
- Calcium
- Diabetic Cardiomyopathies
- Heart Failure
- Mitochondria, Heart
- Myocytes, Cardiac