Integrated transcriptomic-genomic tool Texomer profiles cancer tissues.
basic_science · Level V
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- Record sourced from PubMed, PMID 30988467.
- Also identified by DOI 10.1038/s41592-019-0388-9 and PMC identifier 7337246.
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Abstract
Profiling of both the genome and the transcriptome promises a comprehensive, functional readout of a tissue sample, yet analytical approaches are required to translate the increased data dimensionality, heterogeneity and complexity into patient benefits. We developed a statistical approach called Texomer ( https://github.com/KChen-lab/Texomer ) that performs allele-specific, tumor-deconvoluted transcriptome-exome integration of autologous bulk whole-exome and transcriptome sequencing data. Texomer results in substantially improved accuracy in sample categorization and functional variant prioritization.
Medical subject headings
- Gene Expression Profiling
- Genome, Human
- Genomics
- High-Throughput Nucleotide Sequencing
- Neoplasms
- Transcriptome