Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients.
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Where this comes from
- Record sourced from PubMed, PMID 30992440.
- Also identified by DOI 10.1038/s41467-019-09762-1 and PMC identifier 6467893.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.
Medical subject headings
- Adenocarcinoma of Lung
- Asian People
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Lung Neoplasms