Hear Pancreatic Cancer Stem Cells ROR.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31002791.
- Also identified by DOI 10.1016/j.cell.2019.04.002.
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Abstract
In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
Medical subject headings
- Adenocarcinoma
- Pancreatic Neoplasms