The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31002793.
- Also identified by DOI 10.1016/j.cell.2019.04.003.
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Abstract
Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors.
Medical subject headings
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins