An unexpected role of steroid on podocytes: from zebrafish to human nephrotic syndrome?
other · Level V
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- Record sourced from PubMed, PMID 31010473.
- Also identified by DOI 10.1016/j.kint.2019.01.044.
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Abstract
In this issue of Kidney International, Jobst-Schwan et al. developed a zebrafish model of MAGI2-deficiency, which recapitulates findings of human nephrotic syndrome due to MAGI2 mutations. The authors use this model system to screen for drugs that might target and alleviate MAGI2-associated nephrotic syndrome pathways. The scientific context of this publication and the significance of its key findings are discussed in this commentary.
Medical subject headings
- Nephrotic Syndrome
- Podocytes
- Zebrafish Proteins