ATP responsive DNA nanogels grown on biocompatible branches for anticancer drug delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31012474.
- Also identified by DOI 10.1039/c9sm00480g.
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Abstract
We developed biocompatible ATP responsive DNA nanogels, by grafting DNA strands on carboxymethyl chitosan polymer chains, and then hybridizing with ATP aptamers to form core-shell nanogels. The DNA duplex structure could embed DOX in the G-C sequences, and realize simultaneous sol-gel transition and DOX release when suffering enrich ATP in tumor cells.
Medical subject headings
- Adenosine Triphosphate
- Antineoplastic Agents
- Biocompatible Materials
- DNA
- Drug Carriers
- Nanostructures