Genome-wide association study of medication-use and associated disease in the UK Biobank.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 31015401.
- Also identified by DOI 10.1038/s41467-019-09572-5 and PMC identifier 6478889.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug discovery and can be used to quantify future risk of medication taking. Here, we conduct GWASs of self-reported medication use from 23 medication categories in approximately 320,000 individuals from the UK Biobank. A total of 505 independent genetic loci that meet stringent criteria (P < 10<sup>-8</sup>/23) for statistical significance are identified. We investigate the implications of these GWAS findings in relation to biological mechanism, potential drug target identification and genetic risk stratification of disease. Amongst the medication-associated genes are 16 known therapeutic-effect target genes for medications from 9 categories. Two of the medication classes studied are for disorders that have not previously been subject to large GWAS (hypothyroidism and gastro-oesophageal reflux disease).
Medical subject headings
- Drug Utilization
- Genome, Human
- Genome-Wide Association Study
- Pharmacogenomic Testing
- Prescription Drugs