YAP-independent mechanotransduction drives breast cancer progression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31015465.
- Also identified by DOI 10.1038/s41467-019-09755-0 and PMC identifier 6478686.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, the role of YAP during in vivo breast cancer remains unclear. Here, we find that mechanotransduction occurs independently of YAP in breast cancer patient samples and mechanically tunable 3D cultures. Mechanistically, the lack of YAP activity in 3D culture and in vivo is associated with the absence of stress fibers and an order of magnitude decrease in nuclear cross-sectional area relative to 2D culture. This work highlights the context-dependent role of YAP in mechanotransduction, and establishes that YAP does not mediate mechanotransduction in breast cancer.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Breast Neoplasms
- Carcinoma, Intraductal, Noninfiltrating
- Extracellular Matrix
- Mechanotransduction, Cellular
- Phosphoproteins