How does your fat affect your liver when you drink?
Where this comes from
- Record sourced from PubMed, PMID 31033483.
- Also identified by DOI 10.1172/JCI128984 and PMC identifier 6546464.
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Abstract
White adipose tissue (WAT) dysfunction is generally thought to promote the development of alcoholic liver disease (ALD) in alcoholics by releasing free fatty acids and inflammatory mediators. This explains, at least in part, the synergistic or additive effects of alcohol and obesity on liver disease progression. In this issue of the JCI, Shen et al. establish a previously unrecognized concept that brain alcohol sensing enhances thermogenesis of brown adipose tissue (BAT) through sympathetic nerve activation. BAT functions as hepatoprotective machinery to counteract the development of ALD, implying a therapeutic potential of BAT activity modulation for the treatment of ALD.
Medical subject headings
- Adipose Tissue, Brown
- Fatty Liver