Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens.
basic_science · Level V
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- Record sourced from PubMed, PMID 31036644.
- Also identified by DOI 10.1073/pnas.1818327116 and PMC identifier 6525503.
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Abstract
Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (T<sub>VM</sub>) has been described that possesses many, though not all, features of "true memory" T cells, without the requirement of first encountering cognate antigen. Here, we demonstrate a role for regulatory T cell-mediated restraint of T<sub>VM</sub> at least in part through limiting IL-15 <i>trans</i>-presentation by CD11b+ dendritic cells. Further, we show that keeping T<sub>VM</sub> in check ensures development of functional, antigen-specific "true" memory phenotype CD8+ T cells that can assist in pathogen control upon reexposure.
Medical subject headings
- Immunologic Memory
- T-Lymphocytes, Regulatory