Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31039377.
- Also identified by DOI 10.1016/j.jaci.2019.04.014 and PMC identifier 6688929.
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Abstract
Tamoxifen induces autophagy-dependent NET formation in CGD patient neutrophils and improves their antimicrobial activity. Given the genetic defect in their ROS-generation machinery, this study highlights repurposing of tamoxifen to potentiate host defense in CGD patients.
Medical subject headings
- Extracellular Traps
- Granulomatous Disease, Chronic
- Neutrophils
- Staphylococcal Infections
- Staphylococcus aureus
- Tamoxifen