Nischarin Regulates Secretion of Exosomes and Cancer Progression.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31043427.
- Also identified by DOI 10.1158/0008-5472.CAN-19-0387.
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Abstract
The intercellular exchange of exosomes may play a regulatory function in tumor progression and metastasis. Maziveyi and colleagues demonstrated that Nischarin regulated the secretion of exosomes from breast cancer cells. Loss of Nischarin expression increased exosome production and promoted tumor cell growth and migration, supporting that Nischarin can influence the behavior of surrounding cancer cells. This study identified a novel function of the tumor suppressor Nischarin in exosome biology and cancer progression.<i>See related article by Maziveyi et al., p. 2152</i>.
Medical subject headings
- Breast Neoplasms
- Exosomes