Circle the Wagons: Circular RNAs Control Innate Immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31051101.
- Also identified by DOI 10.1016/j.cell.2019.04.020 and PMC identifier 7112311.
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Abstract
Circular RNAs are generated at low levels from many protein-coding genes. Liu et al. now reveal that many of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR. Upon viral infection, circular RNAs are globally degraded to release PKR, which becomes activated to aid in the immune response.
Medical subject headings
- RNA, Circular
- eIF-2 Kinase