Transcription Factor Stoichiometry Drives Cell Fate: Single-Cell Proteomics to the Rescue.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31051126.
- Also identified by DOI 10.1016/j.stem.2019.03.002.
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Abstract
In this issue of Cell Stem Cell, Palii et al. (2019) use a proteomics approach to investigate the differentiation along the erythroid lineage of human hematopoietic progenitors. They show that antagonistic transcription factor pairs are co-expressed in single progenitors, refuting earlier claims, and that differentiation proceeds along a continuum of cell states.
Medical subject headings
- Hematopoietic Stem Cells
- Transcription Factors