Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31051127.
- Also identified by DOI 10.1016/j.stem.2019.04.003 and PMC identifier 7065719.
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Abstract
In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.
Medical subject headings
- Embryonic Stem Cells
- Induced Pluripotent Stem Cells