Reprogramming Nuclear Architecture: Just a TAD.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31051129.
- Also identified by DOI 10.1016/j.stem.2019.04.007.
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Abstract
In this issue of Cell Stem Cell, Laugsch et al. (2019) use direct reprogramming, epigenetics, and chromatin architecture studies to demonstrate that developmental defects observed in a BOFS patient are caused by reduced expression of TFAP2A in neural crest cells due to the spatial separation of the promoter from its neural crest enhancers.
Medical subject headings
- Induced Pluripotent Stem Cells
- Neural Crest