Pluripotency on Lockdown after Deletion of Three Transcription Regulators.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31051130.
- Also identified by DOI 10.1016/j.stem.2019.04.008.
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Abstract
Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to exit the pluripotent state.
Medical subject headings
- Mouse Embryonic Stem Cells
- Pluripotent Stem Cells