The relationship between spatial configuration and functional connectivity of brain regions revisited.
Where this comes from
- Record sourced from PubMed, PMID 31066676.
- Also identified by DOI 10.7554/eLife.44890 and PMC identifier 6541435.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Previously we showed that network-based modelling of brain connectivity interacts strongly with the shape and exact location of brain regions, such that cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity (Bijsterbosch et al., 2018). Here we show that these spatial effects on connectivity estimates actually occur as a result of spatial overlap between brain networks. This is shown to systematically bias connectivity estimates obtained from group spatial ICA followed by dual regression. We introduce an extended method that addresses the bias and achieves more accurate connectivity estimates.
Medical subject headings
- Brain
- Connectome
- Nerve Net
- Neural Pathways