Position Is Destiny: Metabolism and Cell Identity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31067445.
- Also identified by DOI 10.1016/j.cmet.2019.04.008 and PMC identifier 7066515.
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Abstract
CTNNB1, encoding β-catenin, is frequently mutated in hepatocellular carcinoma, the most rapidly growing solid cancer in the US, and activating mutations in this gene are associated with increased expression of glutamine synthetase. A new report by Adebayo Michael et al. (2019) identifies mTOR as a direct target of WNT/β-catenin signaling through increased production of glutamine, which is required for the carcinogenic effects of WNT/β-catenin activity in the liver.
Medical subject headings
- Carcinoma, Hepatocellular
- Liver Neoplasms