Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31071011.
- Also identified by DOI 10.7554/eLife.41869 and PMC identifier 6508935.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.
Medical subject headings
- Central Nervous System
- Demyelinating Diseases
- Multiple Sclerosis
- Oligodendroglia
- Remyelination
- Transforming Growth Factor beta1