Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti-PD-1 Therapy.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 31074843.
- Also identified by DOI 10.1002/lary.27902.
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Abstract
Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long-term sequelae. We describe four patients who, after complete responses to anti-PD-1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57-year-old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39-year-old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66-year-old male with craniofacial osteoradionecrosis. Patient 4 is a 71-year-old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope, 129:E428-E433, 2019.
Medical subject headings
- Antibodies, Monoclonal, Humanized
- Head and Neck Neoplasms
- Nivolumab
- Otorhinolaryngologic Surgical Procedures
- Programmed Cell Death 1 Receptor
- Squamous Cell Carcinoma of Head and Neck
- Wound Healing