Hepatitis C Virus RNA Levels Following Virologic Failure With Direct-acting Antivirals: Implications for Lower Sensitivity Diagnostic Assays.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 31075159.
- Also identified by DOI 10.1093/cid/ciz385.
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Abstract
We analyzed post-treatment hepatitis C virus (HCV) RNA levels from 330 subjects who experienced virologic failure in clinical trials of direct-acting antivirals. We demonstrated that 97% had post-treatment Week 12 HCV RNA >10 000 IU/mL, above reported sensitivity limits of novel diagnostic assays being considered for simplified HCV treatment monitoring.
Medical subject headings
- Antiviral Agents
- Hepatitis C, Chronic