Overcoming the Blood-Brain Barrier with an Implantable Ultrasound Device.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 31076548.
- Also identified by DOI 10.1158/1078-0432.CCR-19-0932 and PMC identifier 7057332.
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Abstract
Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.<i>See related article by Idbaih et al., p. 3793</i>.
Medical subject headings
- Blood-Brain Barrier
- Pharmaceutical Preparations